Detecting spiral wave tips using deep learning

Abstract

The chaotic spatio-temporal electrical activity during life-threatening cardiac arrhythmias like ventricular fbrillation is governed by the dynamics of vortex-like spiral or scroll waves. The organizing centers of these waves are called wave tips (2D) or flaments (3D) and they play a key role in understanding and controlling the complex and chaotic electrical dynamics. Therefore, in many experimental and numerical setups it is required to detect the tips of the observed spiral waves. Most of the currently used methods signifcantly sufer from the infuence of noise and are often adjusted to a specifc situation (e.g. a specifc numerical cardiac cell model). In this study, we use a specifc type of deep neural networks (UNet), for detecting spiral wave tips and show that this approach is robust against the infuence of intermediate noise levels. Furthermore, we demonstrate that if the UNet is trained with a pool of numerical cell models, spiral wave tips in unknown cell models can also be detected reliably, suggesting that the UNet can in some sense learn the concept of spiral wave tips in a general way, and thus could also be used in experimental situations in the future (ex-vivo, cell-culture or optogenetic experiments).

Publication
Scientific Reports 11: 19767