Research Interests

‘My curiosity for the application of physics in biology and medicine drives me to explore and fundamentally understand these worlds.
I am currently doing research in numerical and experimental biomedical physics with a focus on nonlinear dynamics, cardiac arrhythmias and cardiac optogenetics. The main goal of my projects is the effective control of life-threatening cardiac arrhythmias through a better understanding of their origin, progression and termination mechanisms.’

Curriculum Vitae

Collaborators

• V. N. Biktasheve, Exeter University, United Kingdom
• V. Krinski, INPHYNI, CNRS, Sophia Antipolis, France
• L. Sacconi, Department of Experimental and Clinical Medicine, University of Florence, Italy
• G. Bub,Department of Physiology, MGill University, Montreal, Canada
• E. Bodenschatz, Max Planck Institute for Dynamics and Self-Organization, Göttingen
• V. Zykov, Max Planck Institute for Dynamics and Self-Organization, Göttingen

Publications and related works

• S. Hussaini, Ph.D thesis
  Optogenetic Control of Cardiac Arrhythmias
  eDiss (2021): http://dx.doi.org/10.53846/goediss-9016
  

• S. Hussaini, V. Venkatesan, V. Biasci, J. M. R. Sepúlveda, R. A. Q. Uribe, L. Sacconi, G. Bub, C. Richter, V. Krinski, U. Parlitz, R. Majumder, S. Luther
  Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination
  eLife Highlighted (2021): http://doi.org/10.7554/eLife.59954
  

• E. M Wülfers and F. Schneider-Warme
  Cardiac Optogenetics: A move in the light direction
  Insight (2021): https://doi.org/10.7554/eLife.65360
  

• R. Majumder, S. Hussaini, V. Zykov, S. Luther, E. Bodenschatz
  Pulsed low-energy stimulation initiates electric turbulence in cardiac tissue
  PLOS Computational Biology (2021): https://doi.org/10.1371/journal.pcbi.1009476
  

• V. Biasci, L. Santini, G. A. Marchal, S. Hussaini, C. Ferrantini, R. Coppini, L. M. Loew, S. Luther, M. Campione, C. Poggesi, F. S. Pavone, E. Cerbai, G. Bub, L. Sacconi
  Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms
  Research in Cardiology (2022): https://doi.org/10.1007/s00395-022-00933-8
  

• S. Hussaini, S. L. Lädke, J. Schröder-Schetelig, V. Venkatesan, R. A. Q. Uribe, C. Richter, R. Majumder, S. Luther
  Dissolution of spiral wave’s core using cardiac optogenetics
  PLOS Computational Biology (2023): https://doi.org/10.1371/journal.pcbi.1011660
  

• S. Hussaini, R. Majumder, V. Krinski, S. Luther
  In silico optical modulation of spiral wave trajectories in cardiac tissue
  European Journal of Physiology (2023): https://doi.org/10.1007/s00424-023-02889-7
  

• S. Hussaini, A. Mamyraiym Kyzy, J. Schröder-Schetelig, S. L. Lädke, V. Venkatesan, L. Diaz-Maue, R. A. Quiñonez Uribe; C. Richter, V. N. Biktashev, R. Majumder, V. Krinski, S. Luther
  Efficient termination of cardiac arrhythmias using optogenetic resonant feedback pacing
  Chaos Featured (2024): https://doi.org/10.1063/5.0191519
  

• Avery Thompson
  Low-energy optogenetic technique offers safer arrhythmia treatments
  Scilights (2024): https://doi.org/10.1063/10.0025492